Immune System & Auto-Inflammation

GENETICS, EPIGENETICS & FUTURE-FACING SKIN BIOLOGY

(How your DNA, lifestyle and environment shape the way your skin ages — and how Aeternitas reprograms skin behaviour)

INTRODUCTION — YOUR SKIN IS A GENETIC STORY, BUT YOU CAN REWRITE IT

Every client has asked, at some point:

“Is it just genetics?”

“My family ages quickly — does that mean I will too?”

“I’ve always been prone to pigmentation — can that change?”

“My skin scars easily — is that genetic?”

“I feel like I’m ageing faster than others — why?”

The short answer:

Genetics determine your baseline.

Epigenetics determine your outcome.

Your DNA creates your skin’s natural blueprint:

collagen density
oil activity
pigment behaviour
inflammation response
vascular reactivity
healing speed
pore structure
fibroblast productivity
sensitivity threshold

But your epigenetics — the way your genes behave in response to life — decide how you actually age.

Epigenetics are influenced by:

stress
sleep
hormones
sun exposure
pollution
diet
medication
inflammation
trauma
lifestyle
technology-based treatments

This means:

You can be genetically predisposed to age quickly —

and still age slowly and beautifully with the right support.

You can be genetically prone to pigmentation —

and still maintain clear, even skin tone.

You can be genetically sensitive —

and still achieve calm, resilient skin.

Epigenetics make transformation possible.

WHY THIS PAGE MATTERS

Clients often compare themselves to:

siblings
parents
friends
partners
people their age

And they feel confused:

“Why do I look older than my sister?”

“My friend is the same age, but her skin looks younger.”

“My mum didn’t age until her 60s — why am I ageing in my 40s?”

“Why do I keep getting pigmentation even though I wear SPF?”

“My skin scars more easily than my friends’ skin.”

Genetics can explain some of this.

But the real story is epigenetics.

Epigenetics determine:

how quickly collagen breaks down
how reactive inflammation becomes
how pigment cells behave under stress
whether elastin stays intact
whether wounds heal smoothly
how skin responds to hormonal shifts
how long fibroblasts remain active
how rapidly skin ages

This means that treatments are not fighting fate — they are activating biology.

This page teaches clients exactly how.

HOW GENETICS AND EPIGENETICS AFFECT YOUR DAILY SKIN BEHAVIOUR

Your skin behaves based on:

inherited characteristics
environmental exposures
hormonal rhythms
lifestyle choices
stress load
biological resilience
inflammation history
collagen repair ability
oxidative stress patterns

In reality:

Two people with identical genes can age entirely differently.

Your genes load the gun —

your environment pulls the trigger —

your choices steer the bullet —

and Aeternitas technology can redirect it entirely.

THE FUTURE OF SKIN — REGENERATIVE, ADAPTIVE, PERSONAL

Skin ageing used to be viewed as unavoidable.

Now we know:

fibroblasts can be reactivated
collagen can be rebuilt
DNA damage can be repaired
epigenetic ageing can be slowed
inflammatory genes can be switched off
structural genes can be stimulated
glycation can be reversed
architecture can be lifted
pigment genes can be silenced
metabolic energy can be restored

Aeternitas uses energy-based epigenetic stimulation to influence:

gene expression
cellular behaviour
mitochondrial density
collagen transcription
elastin assembly
vascular resilience
inflammatory signalling

This is the future of aesthetics — and it is already here.

WHAT THIS PAGE COVERS

By the end of Page 6, clients will understand:

DNA vs epigenetics
collagen-genetic variation
pigment-genetic variation
inflammation genetics
scar formation genetics
vascular genetics
skin barrier genetics
how lifestyle changes gene expression
how stress ages skin at the genetic level
how treatments reprogram fibroblast behaviour
how ethnic genetics influence ageing
how gender genetics influence skin structure
DNA ageing vs biological ageing
how HIFU, RF and LED influence gene activity

This page is where clients truly understand why technology can change their future ageing pattern, not just their present appearance.

THE BIOLOGY OF GENETICS, DNA & EPIGENETIC AGEING

(How your inherited blueprint shapes your skin — and how your environment, hormones, stress and treatments can modify it)

GENETICS — YOUR SKIN’S ORIGINAL BLUEPRINT

Your DNA determines your baseline for:

collagen density
elastin quality
fibroblast productivity
pigment behaviour
sensitivity threshold
vascular reactivity
oil activity
pore size
wound-healing capacity
inflammation behaviour
barrier strength

Genetics explain why:

some people naturally have thicker skin
some wrinkle early
some rarely break out
some develop pigment easily
some scar more easily
some flush strongly
some stay youthful for decades

However:

Genetics determine the starting point.

Epigenetics determine the outcome.

GENETIC VARIATION IN COLLAGEN & ELASTIN

Your genes decide how your collagen behaves:

how tightly fibres are organised
how resistant they are to breakdown
how active your fibroblasts are
how densely collagen is packed
how elastic your elastin fibres remain

Some people are genetically “high collagen responders.”

Their fibroblasts:

produce collagen faster
repair injuries more efficiently
resist glycation
maintain firmness longer

Others are genetically “low responders,” meaning:

slower collagen production
quicker breakdown
early fine lines
earlier laxity
thinner dermis
more rapid structural decline

But even low responders can dramatically improve through epigenetic activation — which is precisely what HIFU, RF Microneedling and LED do.

GENETIC VARIATION IN PIGMENT BEHAVIOUR

Genetics influence:

how melanocytes respond to light
how quickly pigment forms
how long it stays
how deep it travels
how inflammation affects pigment
how easily melasma develops

Clients genetically prone to pigment often:

develop sun spots younger
experience PIH more often
have stronger melanin rebound
see slower fading of marks

However:

Pigment genes can be stabilised.

Energy-based vascular, LED and RF modalities can interrupt the pathways that trigger pigmentation.

GENETIC VARIATION IN INFLAMMATION & REDNESS

Inflammation genes determine:

how strongly the skin reacts
how long inflammation lasts
whether redness becomes chronic
sensitivity levels
immune system overactivity
tendency toward rosacea-like behaviour

Some clients naturally mount strong inflammatory responses.

Others remain calm even under stress.

Hormones can intensify genetic inflammatory tendencies — especially progesterone, cortisol and testosterone.

LED and Cryo are essential modulators for genetically reactive skin.

GENETIC VARIATION IN SCARRING & WOUND HEALING

Your wound-healing genes influence:

how easily you scar
how collagen is laid down
whether scars become raised or indented
how smooth healing is
how long redness remains
whether pigmentation appears

This is critical for RF Microneedling and Secret RF clients.

However:

Epigenetic treatment sequencing can override slow genetic healing

by increasing ATP, fibroblast signalling and vascular repair.

GENETIC VARIATION IN OIL & BREAKOUT PATTERNS

Oil-production genes determine:

pore size
breakout likelihood
jawline acne severity
textural thickening
response to hormones
degree of inflammation
skin barrier density

Clients with genetically active sebaceous glands:

experience more hormonal acne
scar more frequently
struggle with persistent congestion

RF + LED + Cryo + 980+ are particularly effective for high-oil genetic profiles.

EPIGENETICS — HOW LIFE REPROGRAMS YOUR DNA

Epigenetics decide how your genes behave.

They turn genes:

ON (active)
OFF (silent)
UP (stronger behaviour)
DOWN (weaker behaviour)

Epigenetic triggers include:

stress
sleep
diet
sun exposure
pollution
inflammation
hormones
medication
trauma
smoking
alcohol
chronic dehydration
UV damage
emotional stress
long-term illness

In the skin, epigenetic triggers change:

collagen production rates
elastin quality
wound-healing speed
barrier function
pigment activity
vascular behaviour
inflammation signalling
sensitivity
breakout likelihood

This means:

Your skin at 40 is not simply the result of your genes — it is the result of gene expression choices made over 10, 20, 30 years.

And the most important insight:

Energy-based treatments can reverse negative epigenetic changes.

HOW STRESS AND CORTISOL MODIFY GENE EXPRESSION

Stress increases cortisol, which epigenetically:

switches ON inflammatory genes
switches ON pigment-activating genes
switches OFF collagen-building genes
switches OFF antioxidant genes
weakens barrier function
reduces fibroblast activity
accelerates overall biological ageing

This is why stress causes clients to say:

“I aged so quickly this year.”

“My skin just changed suddenly.”

“My face collapsed during stress.”

LED, Cryo and RF are essential in reversing cortisol-driven gene expression.

HOW HORMONES MODIFY GENE EXPRESSION

Hormonal changes influence:

collagen transcription genes
pigment-related genes (TYR, MITF pathways)
fibroblast signalling genes
elastin-assembly genes
inflammatory genes (IL-6, IL-8)
barrier lipid-production genes
wound-healing genes

This is why perimenopause and menopause cause sudden visible changes —

the genetic instructions have changed.

HIFU + RF + LED help restore youthful gene expression.

AGEING GENES VS BIOLOGICAL AGEING

Chronological ageing = your age in years.

Biological ageing = how your DNA behaves right now.

Biological ageing is influenced by:

mitochondrial efficiency
collagen transcription levels
inflammation load
epigenetic damage
hormonal environment
oxidative stress
immune balance

Some clients at 50 have a biological skin age of 35.

Some clients at 35 have a biological skin age of 50.

Aeternitas technologies aim to lower biological age, not just improve the surface.

GENETIC PROFILES BY ETHNICITY, GENDER & PREDICTABLE EPIGENETIC AGEING PATTERNS

(Why different people age differently — and why these patterns happen with precision)

GENETICS, ETHNICITY & AGEING — WHY DIFFERENCES ARE REAL

Your ethnicity influences:

collagen density
melanin behaviour
vascular visibility
scarring risk
pigment risk
inflammation patterns
elastin behaviour
dermal thickness
oil activity
healing speed

These inherited factors determine how ageing appears on the surface.

Below is the clearest breakdown ever written for clients and web creators.

FITZPATRICK I–III (LIGHTER SKIN TYPES)

Genetic strengths:

clearer visibility of vascular structure
faster early healing
low melanin reactivity

Genetic vulnerabilities:

redness
flushing
visible capillaries
thinner dermis
more surface wrinkles
earlier fine lines
UV-induced collagen loss
inflammation-driven ageing
barrier sensitivity

Ageing pattern:

early eye area ageing
early fine lines
forehead wrinkles
cheek redness
visibly uneven tone
premature sagging (dermal thinness)

Treatment considerations:

HIFU for structural depth
RF Microneedling to thicken dermis
LED for inflammation
Cryo for vascular instability
980+ for redness correction

FITZPATRICK IV–VI (MEDIUM–DEEP SKIN)

Genetic strengths:

thicker dermis
slower wrinkle development
stronger collagen
slower structural ageing

Genetic vulnerabilities:

pigment reactivity
PIH risk
melasma susceptibility
slow fading of marks
deep inflammation
oil activity variation
hormonal pigment patterns

Ageing pattern:

later wrinkles
later sagging
earlier pigmentation
uneven tone
deeper-set inflammation
under-eye pigment
stronger nasolabial depth with age

Treatment considerations:

RF Microneedling with pigment-safe protocols
LED for pigment-immune control
980+ for microvascular activity
HIFU for mid-face support
Cryo for inflammation reduction

GENETICS BY GENDER — STRUCTURAL DIFFERENCES THAT MATTER

FEMALE GENETIC PATTERN

Features:

thinner dermis genetically
lower collagen density
higher sensitivity
more hormonal fluctuations
rapid collagen decline at menopause
more pigment response
early under-eye thinning

Ageing pattern:

earlier fine lines
earlier pigment
under-eye collapse
neck creping
hormonal redness
cheek deflation
rapid perimenopausal changes

Treatment priorities:

collagen rebuild (RF + HIFU + Secret RF)
LED to stabilise hormones
pigment control (980+)

MALE GENETIC PATTERN

Features:

thicker dermis
stronger collagen
more sebaceous activity
fewer early wrinkles
later but deeper structural ageing
stronger lower-face heaviness
increased vascularity

Ageing pattern:

mid-life rapid sagging
heavier folds
deeper wrinkles
jawline collapse
significant lower-face descent

Treatment priorities:

HIFU for deep SMAS tension
RF for scarring and texture
LED for redness
Cryo for vascular response

TRANSGENDER GENETIC-HORMONAL PATTERNS

MTF (Male-to-Female)

MTF (Male-to-Female)

Before HRT:

masculine collagen density
stronger elastin
thicker dermis

After HRT:

thinning of dermis
increased pigment sensitivity
increased redness
more fragile eye area
feminised structural ageing

Treatment priorities:

Secret RF for thin regions
LED for sensitivity control
pigment and vascular support
HIFU with careful SMAS protocols

FTM (Female-to-Male)

Before HRT:

feminine collagen baseline
more pigment variability
increased sensitivity

After HRT:

increased oil
increased inflammation
acne susceptibility
thicker dermis
stronger collagen network

Treatment priorities:

RF Microneedling
980+ vascular for redness
LED to calm inflammation
Cryo to stabilise oil & swelling

THE FOUR UNIVERSAL EPIGENETIC AGEING PATTERNS

These are the patterns ALL clients fall into — regardless of ethnicity or gender.

Understanding these helps Aeternitas design precise protocols.

The Inflammation-Dominated Ageing Profile

Drivers:

cortisol
stress
hormonal surges
pollution
inflammation genes
trauma
poor sleep

Visible signs:

redness
sensitivity
uneven tone
slow healing
pigment marks
puffiness

Best technologies:

LED
Cryo
RF Microneedling
980+ Vascular

The Pigment-Dominant Ageing Profile

Drivers:

melanocyte hyper-reactivity
genetics
hormones
insulin fluctuations
sun exposure

Visible signs:

melasma
dark patches
uneven tone
PIH
slow fading of marks

Best technologies:

980+
LED
RF Microneedling (with pigment-safe settings)

The Structural Ageing Profile

Drivers:

collagen decline
SMAS weakening
ligament stretching
fat pad descent
hormonal changes
glycation

Visible signs:

sagging
neck laxity
jowls
mid-face flattening
deep wrinkles
eye-area collapse

Best technologies:

HIFU
RF Microneedling
Secret RF
LED

The Dermal-Thinning Ageing Profile

Drivers:

oestrogen loss
genetic thin dermis
MTF HRT
chronic stress
inflammation
rapid hormonal shifts

Visible signs:

crepey texture
fine surface lines
fragile under-eye area
postmenopausal skin changes
poor snap-back

Best technologies:

Secret RF
LED
RF Microneedling (light settings)
Cryo for stability

SUMMARY — GENETICS GIVE THE FRAMEWORK, EPIGENETICS DECIDE THE FUTURE

This is the key message clients must understand:

You may inherit your skin type —

but you do not inherit your skin future.

Your genetics decide where you start.

Your epigenetics decide how you age.

Aeternitas technologies decide how well you rebuild.

This prepares the reader for Pillar B — how the treatments modulate gene expression.

HOW ADVANCED TECHNOLOGY MODIFIES GENE EXPRESSION & REPROGRAMS SKIN BEHAVIOUR

(The epigenetic impact of HIFU, RF Microneedling, Secret RF, LED, Cryo, and 980+ vascular on collagen, inflammation, pigment and ageing genes)

THE FUTURE OF SKIN — TECHNOLOGY THAT TALKS TO YOUR DNA

Epigenetics means your skin behaves based on the “instructions” your genes receive.

Aeternitas technologies work because they:

switch ON collagen-building genes
switch OFF inflammation genes
switch ON wound-repair genes
switch OFF pigment-overproduction genes
switch ON anti-ageing pathways
increase mitochondrial activity
instruct fibroblasts to behave younger
increase ECM rebuilding signals
strengthen vascular resilience

Your skin literally receives new biological commands.

This is why results continue improving for months.

EXFU 11D HIFU — GENE ACTIVATION FOR COLLAGEN, LIFTING & ARCHITECTURE

HIFU creates controlled thermal coagulation points at precise depths.

This triggers:

Heat Shock Protein Activation (HSP70, HSP90)

These proteins repair misfolded collagen, increase longevity of fibroblasts, and reactivate anti-ageing genes.

Collagen Transcription Activation (COL1A1, COL3A1)

HIFU tells fibroblasts to produce more Type I and III collagen.

Upregulation of SMAS Tension Genes

SMAS responds by contracting and reorganising its fibre networks — a non-surgical lifting effect.

Epigenetic Reset of Fibroblast Productivity

Fibroblasts behave “younger” for months.

Downregulation of MMPs (Collagen-Degrading Enzymes)

HIFU reduces enzymes that break down collagen, slowing ageing.

This is why HIFU is the main epigenetic tool for:

structural ageing
sagging
menopausal collagen loss
jawline softening
male lower-face heaviness

EXFU 980+ RF MICRONEEDLING — THE EPIGENETIC MASTER SWITCH

RF Microneedling is the strongest epigenetic modulator after HIFU.

It changes gene expression in multiple layers:

Upregulates Collagen & Elastin Genes

COL1A1
COL3A1
ELN (elastin gene)

Upregulates Growth Factors

VEGF (new blood vessels)
TGF-β (collagen signalling)
PDGF (repair stimulation)

Downregulates Inflammatory Genes

IL-6
IL-8
TNF-α

This is crucial for:

hormonal acne
inflammatory ageing
PCOS-related breakouts
MTF sensitivity
FTM inflammation
cortisol-driven skin ageing

Rebuilds ECM Gene Pathways

RF instructs fibroblasts to rebuild:

hyaluronic acid
glycosaminoglycans
proteoglycans

This thickens the dermis.

Anti-Glycation Gene Activation

RF helps reverse stiff, sugar-damaged collagen — a major cause of rapid ageing.

SECRET RF — EPIGENETIC REPAIR FOR THIN, FRAGILE, HORMONE-IMPACTED SKIN

Secret RF uses ultra-controlled RF delivery.

It stimulates:

collagen transcription
ECM rebuilding
elastin gene activity
capillary stabilisation
anti-inflammatory gene pathways
healing genes in fragile zones

It’s essential for:

menopausal thin skin
under-eye collapse
MTF under-eye thinning
delicate mouth-area lines
neck crepe
fine-textured clients
genetically thin dermis

Secret RF modifies gene expression without overheating or damaging sensitive tissue.

DERMALUX LED — THE IMMUNE & HORMONAL EPIGENETIC MODULATOR

LED is the safest epigenetic treatment for reactive or hormonally sensitive clients.

LED influences:

Inflammation Gene Downregulation

IL-1
IL-6
TNF
COX-2

Upregulation of ATP Production Genes

LED increases mitochondrial gene activity → more cellular energy → more collagen.

Upregulation of Healing & Anti-Ageing Genes

LED increases IGF-1 and FGFs → faster repair.

Downregulation of Pigment Activation Genes

LED reduces MITF pathway activation → stabilising discolouration.

Strengthens Skin Barrier Genes

Helps clients with hormonal or stress-driven barrier weakness.

LED is the foundation for:

cortisol-driven ageing
progesterone sensitivity
FTM inflammation
MTF redness
perimenopausal instability
PCOS inflammation
rosacea-type behaviour

CRYO COLD HAMMER — EPIGENETIC COOLING & IMMUNE STABILISATION

Cryo stabilises:

vascular genes
inflammation genes
oedema-related pathways
swelling responses
sensory nerve activation

It downregulates inflammatory cytokine pathways and helps “reset” skin that is epigenetically overstimulated.

Excellent for:

hormonal redness
progesterone swelling
cortisol spikes
hot-flush redness
male vascular reactivity
MTF vascular changes

Cryo acts as the reset switch for reactive skin.

EXFU 980+ VASCULAR — PIGMENT, REDNESS & MICROVASCULAR GENE MODULATION

980+ influences:

Vascular-Stability Genes

Shrinks and stabilises overactive vessels.

Downregulates Inflammatory Pigment Genes

Reduces MITF, TYR and pigment messenger activity in hormone-driven pigment.

Reduces Redness Genes

Calms VEGF and inflammatory nitric oxide pathways.

Improves Microcirculation and Oxygenation

Better blood flow → better healing → better collagen formation.

Essential for:

melasma
stress pigmentation
perimenopausal pigment
hormonal redness
PCOS redness
FTM androgen redness
MTF estrogen flushing

This technology prevents pigment from reappearing — correcting the epigenetic cause, not just the colour.

THE AETERNITAS EPIGENETIC RESET SEQUENCE

Stabilise inflammation (LED + Cryo + Vascular)
Rebuild dermis (RF Microneedling + Secret RF)
Rebuild architecture (HIFU)
Correct pigment/redness (980+)
Maintain epigenetic balance (LED)

This is the epigenetic blueprint for reversing visible skin ageing.

CLIENT LEARNING — “Why Your Skin Doesn’t Age the Same Way as Your Family — and Why That’s a Good Thing”

Most clients carry quiet worries about their genetic future:

“I look like my mum when she started ageing.”

“My dad aged quickly — will I?”

“My older sister looks younger than me.”

“My family ages badly — I’m terrified I will too.”

“My mum got pigmentation early — and now I am.”

“We all have heavy jowls in our family.”

This page rewrites that narrative.

GENETICS ARE YOUR STARTING POINT — NOT YOUR DESTINY

You inherit:

collagen structure
pigment behaviour
oil activity
fibroblast density
vascular visibility
dermal thickness
healing tendencies
inflammation patterns

But you do not inherit:

the age you will look
how fast you will age
how your skin will react to stress
how your hormones will shift
the behaviour of your adult skin
the pace of collagen decline
the severity of sagging
the onset of pigmentation

Your environment, lifestyle, hormones and stress signals rewrite your genes daily.

This means two things:

You can look younger than your biological family pattern.
You can avoid the ageing traits you’re worried about.

Epigenetics gives you control.

WHY YOU DON’T LOOK LIKE YOUR PARENTS (EVEN IF YOU FEAR YOU WILL)

Your parents lived:

different stress
different sleep patterns
different hormonal events
different environmental exposure
different diets
different skincare habits
different sun protection
different lifestyles
different medical histories

Their epigenetics shaped how they aged.

Yours will shape how you age.

This is why:

siblings can look 10 years apart
twins can age differently
friends with similar genetics age completely differently

Your skin is not simply inherited —

it is responding to your life.

WHY YOUR SKIN SOMETIMES AGES FASTER THAN EXPECTED

External triggers can “switch on” rapid ageing genes:

stress
trauma
illness
hormonal changes
pregnancy
perimenopause
inflammation
chronic sleep loss
emotional burnout
UV damage
unhealthy microbiome
pollution
smoking
dehydration

These triggers accelerate biological age — even in clients with strong genetics.

This is why many clients say:

“I aged so quickly in the last 2 years.”

It is not genetics.

It is epigenetic acceleration.

And it is reversible.

WHY YOUR SKIN CAN LOOK YOUNGER THAN EXPECTED

Positive triggers switch ON youthful genes:

regular LED
controlled RF
collagen stimulation
reduced inflammation
improved circulation
balanced hormones
low stress
strong sleep rhythm
SPF protection
balanced nutrition

These “youthful signals” lower biological ageing — even if you have weak genetics.

This is why clients often say:

“I look better now at 40 than I did at 30.”

Epigenetics enables that transformation.

WHY TREATMENTS WORK — EVEN IF YOU THINK YOU HAVE “BAD GENES”

The emotion clients rarely say out loud:

“I don’t think treatments will work for me because I have bad skin genetics.”

Here’s the truth:

Advanced technologies reprogram gene expression.

This means:

fibroblasts behave younger
collagen genes switch on
inflammation genes switch off
pigment genes stabilise
wound healing improves
elastin pathways strengthen
structural genes activate
mitochondrial activity increases

Your DNA isn’t being changed —

but the way your DNA behaves is being changed.

This is why results continue for months after treatment.

YOU ARE NOT FIGHTING YOUR GENES — YOU ARE GUIDING THEM

Clients often feel trapped by their family history.

But the reality is:

Your genes load the gun.

Your lifestyle pulls the trigger.

Your treatments guide the bullet.

Aeternitas technologies:

lift your architecture
rebuild your collagen
reverse inflammation
correct pigment
improve healing
stabilise hormonal skin
support youth genes

You are not stuck with a pre-written script.

Your skin is dynamic — and responsive.

YOU CAN AGE DIFFERENTLY — AND BETTER — THAN EVERYONE YOU’RE RELATED TO

This is the emotional truth that clients need to hear:

You can age beautifully, confidently and youthfully —

even if your parents or siblings aged differently.

You are not bound by the past.

Your skin is adaptable, programmable and rebuildable.

This Science Hub page exists to show clients:

You can rewrite your skin’s future

— beginning at the genetic level.